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These findings suggest that the hypothetical detrimental effects of statins on the function of skeletal and cardiac muscle (and other physiological processes) do not result in important clinical consequences, nor was there any suggestion of the hypothetical risk of further reduction in LDL cholesterol in patients with already low levels.
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Nicholls of two high intensity statin regimens including atorvastatin and rosuvastatin on people of different age groups.
The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes.
Dyslipidemia in children with CKD: should we treat with statins?
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An alternative explanation for the lack of treatment benefit is that rosuvastatin caused harm in a subgroup of patients, which offset a larger benefit in the remainder.
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Homozygous familial hypercholesterolemia where APO-ROSUVASTATIN is used either alone or as an adjunct to diet and other lipid lowering treatments such as apheresis.
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Systemic analysis of PPARgamma in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
In general, the safety profile in this trial was consistent with that of the previously established safety profile in adults.
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To ensure that, at baseline, all patients had LDL cholesterol levels consistent with then-current guidelines for the treatment of stable CHD, patients with LDL cholesterol levels between 130 and 250 mg per deciliter (3.
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This finding indicated the need of careful monitoring of atorvastatin acid therapy in the kidney transplant recipients who are on multiple medications and also have lifetime co-morbidities.
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Similarly, the reduction in LDL ("bad cholesterol") was not significantly different between the groups at one year (-34.
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The revelation that statin cholesterol drugs may be of little or no benefit, as revealed in a lengthy in January 28 issue of Business Week (BW) magazine, begs the question: how did this misdirection go on for so long?
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