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Source: Kolb DA. Experiential learning: Experience as the source of learning and development.
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Participants assigned to disulfiram reduced their cocaine use more than the placebo group, and the results were confirmed by urine analysis.
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Therefore, an individual level prospective clinical trial is unlikely to capture the community level effect of OEND unless it uses a multisite or social network design or measures community level outcomes to account for the network effects and potential contamination between individual participants.
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These different mechanisms of action and different target neurotransmitter systems may endow the two drugs with efficacy for different aspects of alcohol use behavior.
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Prevalence of alcohol and illicit drugs in blood specimens from drivers involved in traffic law offenses.
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Credible, educational campaigns in the mass media about the consequences of alcohol abuse have been recommended.
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Generally, this treatment did not result in significant alterations in biochemical or hematological parameters, nor in relative organ weights, but some changes were noted in (GSH) concentration, and in the activity of (GPx).
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Havlir, D. Strategies on the HIV Epidemic among Men Who Have Sex with Men in San Francisco.
Considerations for Determining if a Natural Product Is an Effective Wound-Healing Agent".
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Effects appear to be mediated through the inhibitory neurotransmitter GABA; the site and mechanism of action within the CNS appear to involve a macromolecular complex (GABA A-receptor-chloride ionophore complex) that includes GABA A receptors, high-affinity benzodiazepine receptors, and chloride channels.
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DESPITE THE IMPORTANCE OF NUMEROUS PSYCHOSOCIAL FACTORS, AT ITS CORE, DRUG ADDICTION INVOLVES A BIOLOGICAL PROCESS: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use, that define a state of addiction.
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